Raf Kinase Inhibitor Protein RKIP Enhances Signaling by Glycogen Synthase Kinase-3β
نویسندگان
چکیده
منابع مشابه
Raf kinase inhibitor protein RKIP enhances signaling by glycogen synthase kinase-3β.
Raf kinase inhibitory protein (RKIP) is a physiologic inhibitor of c-RAF kinase and nuclear factor κB signaling that represses tumor invasion and metastasis. Glycogen synthase kinase-3β (GSK3β) suppresses tumor progression by downregulating multiple oncogenic pathways including Wnt signaling and cyclin D1 activation. Here, we show that RKIP binds GSK3 proteins and maintains GSK3β protein levels...
متن کاملMolecular and Cellular Pathobiology Raf Kinase Inhibitor Protein RKIP Enhances Signaling by Glycogen Synthase Kinase-3b
Raf kinase inhibitory protein (RKIP) is a physiologic inhibitor of c-RAF kinase and nuclear factor kB signaling that represses tumor invasion andmetastasis.Glycogen synthase kinase-3b (GSK3b) suppresses tumorprogression by downregulating multiple oncogenic pathways including Wnt signaling and cyclin D1 activation. Here, we show thatRKIPbindsGSK3proteins andmaintainsGSK3bprotein levels and its a...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2011
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-10-3102